Description

Ipamorelin is a synthetic pentapeptide and growth hormone secretagogue that acts as a ghrelin receptor agonist to stimulate pulsatile growth hormone release from the pituitary.pubchem.ncbi.nlm.nih+1

Core description

Its sequence is commonly given as Aib-His-D-2-Nal-D-Phe-Lys-NH2, and it is known for being relatively selective for growth hormone compared with older secretagogues.pubchem.ncbi.nlm.nih+2
That selectivity means it typically does not meaningfully raise cortisol, prolactin, LH, FSH, or TSH in the way some other peptides can.pubchem.ncbi.nlm.nih+1

Main research interest

Ipamorelin is studied for its effects on growth hormone and downstream IGF-1 signaling, which are relevant to muscle, recovery, bone, and body composition research.