How MOTS-c Works Energy Sensor Activation: It targets skeletal muscle and activates AMPK (AMP-activated protein kinase), the body’s primary master energy sensor.  Metabolic Shift: It mimics the physiological effects of fasting or high-intensity exercise by forcing cells to burn stored fatty acids and increase glucose absorption.  Mitochondrial Biogenesis: It stimulates the replication of mitochondrial DNA and enhances overall cellular energy production.  Potential Benefits & Research Focus Improved Insulin Sensitivity: Preclinical studies show it helps combat diet- and age-dependent insulin resistance and obesity